Pyritinol and Phosphatidylserine

Ann. New York Acad. Sci., 1993, 695/- (327-331)


Forty patients with probable Alzheimer's disease were selected from a pool of 80 patients and assigned to four groups.  Each received either social support, cognitive training only, or cognitive training in combination with pyritinol or phosphatidylserine. Treatment duration was 6 months.  Before and after treatment the patients underwent neuropsychological testing as well as measurement of the regional cerebral metabolic rate for glucose using positron emission tomography (PET) and 2(18F)-fluoro-2-deoxy-D-glucose (FDG). Before treatment, the groups were comparable in respect to resting and activated glucose pattern achieved by a visual recognition task. They did not differ in scores of a neuropsychological test battery.

After the treatment period the group with cognitive training plus phosphatidylserine showed a significant glucose enhancement during the stimulation tasks in various brain regions, and an improvement in cognitive functioning compared to other groups. The group with cognitive training plus pyritinol had better stimulation effect than that of the social support group, indicating that a combination of cognitive training and pharmacological intervention was superior than that of cognitive training alone.

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